Antihypertensive action of acebutolol (Sectral) when used concomitantly with hydrochlorothiazide.
نویسندگان
چکیده
منابع مشابه
On the mechanism of antihypertensive action of hydrochlorothiazide in rats.
• Chlorothiazide and congeners, such as hydrochlorothiazide, have been shown to decrease the blood pressure in hypertensive patients' and animals. Indeed, all potent diuretics have been suggested to possess some antihypei-tensive properties either alone or in combination with other agents.' B Two consequences of the diuretic action of chlorothiazide have been postulated to account for its hypot...
متن کاملOn the Mechanism of Antihypertensive Action of Hydrochlorothiazide in Rats
• Chlorothiazide and congeners, such as hydrochlorothiazide, have been shown to decrease the blood pressure in hypertensive patients' and animals. Indeed, all potent diuretics have been suggested to possess some antihypei-tensive properties either alone or in combination with other agents.' B Two consequences of the diuretic action of chlorothiazide have been postulated to account for its hypot...
متن کاملCardiovascular effects of acebutolol and hydrochlorothiazide in essential hypertension.
During a double-blind crossover study of hydrochlorothiazide (HCT) and acebutolol (ACB), 11 patients 45 to 69 years old with essential hypertension underwent studies of forearm blood flow (FBF), arterial resistance (FAR), and venous compliance (FVC) using mercury-in-Silastic plethysmography. Placebo periods of 12 weeks were followed by a variable period of incremental doses of either active dru...
متن کاملProton-pump inhibitors could be innocent when used concomitantly with clopidogrel.
proton-pump inhibitor (PPI) is recommended for patients with a high risk of gastrointestinal bleeding induced by nonsteroidal anti-inflammatory drugs (NSAIDs).1,2 PPIs utilize CYP2C19, a liver enzyme of cytochrome P450, for their inactivation, and this same enzyme mediates the generation of the active substance from the prodrug, clopidogrel, a platelet ADP-receptor blocker.1,2 Therefore, concer...
متن کاملMechanism of antihypertensive action of prolonged administration of hydrochlorothiazide in rabbit and dog.
The effect of hydrochlorothiazide on vascular reactivity to various drugs was studied in rabbit and dog. In rabbit, dose response in the mesenteric artery and vein was examined in vitro following a treatment with hydrochlorothiazide for 6 to 10 weeks. Norepinephrine produced significantly less contraction in the vein of treated than of control animals (P < 0.005), but the effect of aeetylcholin...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1982
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1982.tb01358.x